Abstract
Purpose: Gallstones represent one of the main causes of acute pancreatitis. The aim of this study was to evaluate laparoscopic cholecystectomy results due to acute pancteatitis and compare the surgical results with patients who are operated on symptomatic cholecystolithiasis.
Patients and Methods: Eighty-six patients have underwent cholecystectomy because of acute biliary pancreatitis (Group 1), 93 patients have underwent cholecystectomy because of symptomatic cholecystolithiasis (Group 2). Patients with mild acute pancreatitis were operated in the initial hospitalization. Groups were compared by age, race, previous abdominal surgery, severity of acute pancreatitis, leukocytosis, operative time, conversion to open surgery, postoperative complications, drain management, mortality rates and hospitalization period.
Results: There were no differences regarding conversion rates to open surgery (p=0,34) and wound infection rates (p=0,32). There were no differences regarding postoperative hospitalization period in both groups (p=0,2406) (median 3 days in group 1 and 2 days in group 2). Fourteen patients had severe acute pancreatitis (16%) and open surgery was performed in 7 (50%) of these patients. In mild acute pancreatitis patients only 4 (4,1%) conversion to open surgery had occured. Cholecystectomy was performed ,in 68 (94,4%) mild acute pancreatitis patients and in 12 (85,7%) severe form in the initial hospitalization.
Conclusion: Laparoscopic cholecystectomy can be performed confidently during the index hospitalization after amelioration of the pancreatitis. However, the most important factor that affects the feasibility of laparoscopic cholecystectomy is the severity of the disease. Therefore, laparoscopic cholecystectomy should be postponed until the resolution of the pancreatic and peripancreatic inflammation.
Keywords:
Acute biliary pancreatitis, laparoscopic cholecystectomy, pancreatitis
References
1Banks PA. Epidemiology, natural history, and predictors of disease outcome in acute and chronic pancreatitis. Gastrointest Endosc 2002;56:226–230. doi:10.1067/ mge.2002.129022
2Werner J, Z'Graggen K, Fernandez-del Castillo C, et al. Specific therapyfor local and systemic complications of acute pancreatitis with mono clonal antibodies against ICAM-1. Ann Surg 1999;229: 834– 840. doi:10.1097/00000658-199906000- 00010
3Sinha R. Early laparoscopic cholecystectomy in acute biliary pancreatitis: theoptimal choice? HPB 2008; 10: 332–335. doi:10.1080/13651820802247078
4Yaşar M, Taşkın Ak, Özaydın İ, Demiraran Y. Batı Karadeniz bölgesindeki akut pankreatitli hastaların retrospektif analizi. Düzce Tıp Dergisi 2010; 12: 45-49.
5Moreau JA, Zinsmeister AR, Melton L III, DiMagno EP. Gallstone pancreatitis and the effect of cholecystectomy: a population- based cohortstudy. Mayo Clin Proc 1988;63:466–473.
6Rhodes M, Armstrong CP, Longstaff A, Cawthorn S. Laparoscopic cholecystectomy with endoscopic retrogradecholangio pancreatography for acute gallstone pancreatitis. Br J Surg 1993;80:247. doi:10.1002/bjs.1800800244
7Tate JJ, Lau WY, Li AK. Laparoscopic cholecystectomy for biliary pancreatitis. Br J Surg 1994;81:720–722. doi:10.1002/ bjs.1800810533
8Ballestra-Lopez C, Bastida-Vila X, Bettonica- Larranaga C, Zaraca F, Catarci M. Laparoscopic management of acute biliary pancreatitis. Surg Endosc 1997;11:718–721. doi:10.1007/s004649900435
9Ricci F, Castaldini G, de Manzoni G, Borzellino G, Rodella L, Kind R. Minimallyinvasivetreatment of acutebiliarypancreatitis. Surg Endosc 1997;11:1179–1182. doi:10.1007/s004649900564
10Uhl W, Muller CA, Krahenbuhl L, Schmid SW, Scholzel S, Buchler MW. Acute gallstone pancreatitis: timing of laparoscopic cholecystectomy in mildand severe disease. Surg Endosc 1999;13:1070–1076. doi:10.1007/s004649901175
11Chang L, Lo S, Stabile BE, Lewis RJ, Toosie K, de Virgilio C. Preoperative versus postoperative endoscopic retrogradecholangio pancreatography in mild to moderate gallstone pancreatitis: a prospective randomized trial. Ann Surg 2000;231:82–87. doi:10.1097/00000658-200001000-00012
12Kapan M, Beyazıt Ü, Gümüş M, Önder A, Yağmur Y. Akut biliyer pankreatitli hastalarda erken laparoskopik kolesistektomi sonuçları. Klin Den Ar Derg 2010;1:21-24.
13Ranson JHC, Rifkind KM, Ros es DF. Prognostic sings and the role of operative management in acute pancreatitis. Surg Gynecol Obstet, 1974; 139: 69-81.
14Knaus W, Draper E, Wagner DP. APACHE II: a severity of disease classification system. Crit Care Med 1985; 77: 633-638. doi:10.1097/00003246-198608000- 00028
15Sharma VK, Howden CW. Meta-analysis of randomized controlled trials of endoscopic retrograde cholangiography and endoscopic sphincterotomy for the treatment of acute biliary pancreatitis. Am J Gastroenterol 1999;94:3211–3214.
16Uhl W, Warshaw A, Imrie C, Bassi C, McKay CJ, Lankisch PG, et al. IAP guidelines for the surgical management of acute pancreatitis. Pancreatology 2002;2:565– 573. doi:10.1159/000067684
17Ranson JH. The timing of biliary surgery in acute pancreatitis. Ann Surg 1979;189:654–663. doi:10.1097/00000658- 197905000-00016
18Frei GJ, Frei VT, Thirlby RC, McClelland RN. Biliary pancreatitis: clinical presentation and surgical management. Am J Surg 1986;151:170–175. doi:10.1016/0002- 9610(86)90028-0
19Turhan AN, Kapan S, Gönenç M, Öner OZ, Alış H, Dolay K, Aygün E. Tekrarlayan biliyer pankreatitlerde tedavi. Bakırköy Tıp Dergisi 2009;5:25-27.
20Wilson CT, de Moya MA Cholecystectomy for acute gallstone pancreatitis: early vs delayed approach. Scand J Surg 2010;99: 81–85.