Laparoscopic cholecystectomy in patients with liver cirrhosis
PDF
Cite
Share
Request
Original Article
VOLUME: 26 ISSUE: 3
P: 146 - 152
September 2010

Laparoscopic cholecystectomy in patients with liver cirrhosis

Turk J Surg 2010;26(3):146-152
1. Türkiye Yüksek İhtisas Eğitim ve Araştırma Hastanesi, Gastroenteroloji Cerrahi Kliniği, Ankara
No information available.
No information available
PDF
Cite
Share
Request

Abstract

Purpose: In this study, we aimed to evaluate surgical outcomes of cirrhotic patients who underwent laparoscopic cholecystectomy for gallstones in our clinic. Patients and Methods: From 2003-2009, 18 cirrhotic patients underwent laparoscopic cholecystectomy for gallstones in our clinic. Investigated variables included age, gender, etiology of cirrhosis, Child-Pugh score, MELD score, ASA score, associated medical conditions, biliary pathology, preoperative laboratory parameters, operating time, conversion, use of drain, postoperative complications, reoperation and length of hospital stay. Results: Thirteen patients (72.2%) were female and 5 (27.8%) were male. The median age was 61 years (range 34 - 80 years). Cirrhosis etiology was viral hepatitis in 5 patients, alcohol in 1, cryptogenic in 1, cardiogenic in 1, and in the ten remaining patients, liver cirrhosis could be identified only after intraoperative findings. Seventeen patients were classified as Child-Pugh A and one patient as Child- Pugh B. The median MELD score was 8 (range 6-16) and the median ASA score was 2 (range 1-3). The average operative time was 44 minutes (range 15-100 minutes). One patient required conversion to open surgery (5.6%). Drains were used in 11 patients (61.1%). Postoperative bleeding complications occured in two patients (11.1%). One patient was reoperated on for bleeding (5.6%). The median hospital stay was 2 days (range 1-7 days). The median follow-up period was 52 months (range 6-87 months). Conclusion: This study demonstrates that laparoscopic cholecystectomy can be performed with acceptable morbidity in compensated cirrhotic patients. However, these operations should be carried out in an experienced center for hepato-biliary surgery to obtain the best surgical outcomes.

Keywords:
Laparoscopic cholecystectomy, Liver cirrhosis, Gallstones

References

1
Aranha GV, Sontag SJ, Greenlee HB. Cholecystectomy in cirrhotic patients: a formidable operation. Am J Surg 1982; 43: 55-60.
2
Schwartz SI. Biliary tract surgery and cirrhosis: a critical combination. Surgery 1981; 90: 577-583.
3
Bloch RS, Allaben RD, Walt AJ. Cholecystectomy in patients with cirrhosis. A surgical challenge. Arch Surg 1985; 120: 669-672.
4
Nicholas P, Rinaudo PA, Conn HO. Increased incidence of cholelithiasis in Laënnec's cirrhosis. A postmortem evaluation of pathogenesis. Gastroenterology 1972; 63: 112-121.
5
Bouchier IA. Postmortem study of the frequency of gallstones in patients with cirrhosis of the liver. Gut 1969; 10: 705-710.
6
Davidson JF. Alcohol and cholelithiasis: a necropsy survey of cirrhotics. Am J Med Sci 1962; 244: 703-705.
7
McSherry CK, Glenn F. The incidence and causes of death following surgery for nonmalignant biliary tract disease. Ann Surg 1980; 191: 271-275.
8
Cryer HM, Howard DA, Garrison RN. Liver cirrhosis and biliary surgery: assessment of risk. South Med J 1985; 78: 138-141.
9
Sirinek KR, Burk RR, Brown M, Levine BA. Improving survival in patients with cirrhosis undergoing major abdominal operations. Arch Surg 1987; 122: 271-273.
10
Doberneck RC, Sterling WA Jr, Allison DC. Morbidity and mortality after operation in nonbleeding cirrhotic patients. Am J Surg 1983; 146: 306-309.
11
Trondsen E, Reiertsen O, Andersen OK, Kjaersgaard P. Laparoscopic and open cholecystectomy. A prospective, randomized study. Eur J Surg 1993; 159: 217-
12
Korolija D, Sauerland S, Wood-Dauphinée S et al. European Association for Endoscopic Surgery. Evaluation of quality of life after laparascopic surgery: evidence- based guidelines of the European Association for Endoscopic Surgery. Surg Endosc 2004; 18: 879-897.
13
Garrison RN, Cryer HM, Howard DA, Polk HC Jr. Clarification of risk factors for abdominal operations in patients with hepatic cirrhosis. Ann Surg 1984; 199: 648-655.
14
Friedman LS. The risk of surgery in patients with liver disease. Hepatology, 1999; 29: 1617-1623.
15
Teh SH, Nagorney DM, Stevens SR et al. Risk factors for mortality after surgery in patients with cirrhosis. Gastroenterology. 2007; 132: 1261-1269.
16
Delis S, Bakoyiannis A, Madariaga J et al. Laparoscopic cholecystectomy in cirrhotic patients: the value of MELD score and Child-Pugh classification in predicting outcome. Surg Endosc 2010; 24: 407-412.
17
Kao LS, Aaron BC, Dellinger EP. Trials and tribulations: current challenges in conducting clinical trials. Arch Surg 2003; 138: 59-62.
18
Li JH, Zheng CZ, Ke CW, Yin K. Management of aberrant bile duct during laparoscopic cholecystectomy. Hepatobiliary Pancreat Dis Int 2002; 1: 438-441.
19
D'Albuquerque LA, de Miranda MP, Genzini T et al. Laparoscopic cholecystectomy in cirrhotic patients. Surg Laparosc Endosc 1995; 5: 272-276.
20
Power C, Maguire D, McAnena OJ, Calleary J. Use of the ultrasonic dissecting scalpel in laparoscopic cholecystectomy. Surg Endosc 2000; 14: 1070-1073.
21
Glavić Z, Begić L, Rozman R. A new device for the detection and recognition of blood vessels in laparoscopic surgery. Surg Endosc 2002; 16: 1197-1200.
22
Talamini MA. Controversies in laparoscopic cholecystectomy: contraindications, cholangiography, pregnancy and avoidance of complications. Baillieres Clin Gastroenterol 1993; 7: 881-896.
23
Ercan M, Bostanci EB, Ozer I et al. Postoperative hemorrhagic complications after elective laparoscopic cholecystectomy in patients receiving long-term anticoagulant therapy. Langenbecks Arch Surg 2010; 395: 247–253.
24
Cuschieri A, Dubois F, Mouiel J et al. The European experience with laparoscopic cholecystectomy. Am J Surg 1991; 161: 385-387.
25
The Southern Surgeons Club. A prospective analysis of 1518 laparoscopic cholecystectomies. N Eng J Med 1991; 324: 1073-1078.
26
Puggioni A, Wong LL. A metaanalysis of laparoscopic cholecystectomy in patients with cirrhosis. J Am Coll Surg 2003; 197: 921-926.
27
Ercan M, Bostanci EB, Ulas M et al. Effects of previous abdominal surgery incision type on complications and conversion rate in laparoscopic cholecystectomy. Surg Laparosc Endosc Percutan Tech 2009; 19: 373-378.
28
Rosen M, Brody F, Ponsky J. Predictive factors for conversion of laparoscopic cholecystectomy. Am J Surg 2002; 184: 254-258.
29
Bingener-Casey J, Richards ML, Strodel WE et al. Reasons for conversion from laparoscopic to open cholecystectomy: a 10-year review. J Gastrointest Surg 2002; 6: 800-805.
30
Gibney EJ. Asymptomatic gallstones. Br J Surg 1990; 77: 368–372.
31
Orozco H, Takahashi T, Mercado MA, et al. Long-term evaluation of asymptomatic cholelithiasis diagnosed during abdominal operation for variceal bleeding in patients with cirrhosis. Am J Surg 1994; 168: 232–234.
32
Juhasz ES, Wolff BG, Meagher AP et al. Incidental cholecystectomy during colorectal surgery. Ann Surg 1994; 219: 467–474.
33
Ouriel K, Ricotta JJ, Adams JT, Deweese JA. Management of cholelithiasis in patients with abdominal aortic aneurysm. Ann Surg 1983; 198: 717–719.
34
Klaus A, Hinder RA, Swain J, Achem SR. Incidental cholecystectomy during laparoscopic antireflux surgery. Am Surg 2002; 68: 619–623.
35
Shennib H, Fried GM, Hampson LG. Does simultaneous cholecystectomy increase the risk of colonic surgery? Am J Surg 1986; 151: 266–268.
36
Watemberg S, Landau O, Avrahami R et al. Incidental cholecystectomy in the over-70 age group. A 19-year retrospective, comparative study. Int Surg. 1997; 82: 102–104.
37
Castaing D, Houssin D, Lemoine J, Bismuth H. Surgical management of gallstones in cirrhotic patients. Am J Surg 1983; 146: 310–313.
38
Silva MA, Wong T. Gallstones in chronic liver disease. J Gastroint Surg 2005; 9: 739–746.
39
Podda M, Zuin M, Battezzati PM et al. Efficacy and safety of a combination of chenodeoxycholic and ursodeoxycholic for gallstone dissolution: a comparison with ursodeoxycholic acid alone. Gastroenterology 1989; 96: 222-229.
40
Sackmann M, Pauletzki J, Sauerbruch T et al. The Munich gallbladder lithotripsy study. Results of the first 5 years in 711 patients. Ann Intern Med 1991; 114: 290-
41
Edison SA, Maier M, Kohler B et al. Direct dissolution of gallstones with methyl tert-butyl ether by endoscopic cannulation of the gallbladder. Am J Gastroenterol 1993; 88: 1242-1248.
42
Hofmann AF, Amelsberg A, Esch O et al. Successful topical dissolution of cholesterol gallbladder stones using ethyl propionate. Dig Dis Sci 1997; 42: 1274-1282.
43
Ishizaki Y, Bandai Y, Shimomura K et al. Management of gallstones in cirrhotic patients. Surg Today 1993; 23: 36-39.
44
Currò G, Cucinotta E. Percutaneous gall bladder aspiration as an alternative to laparoscopic cholecystectomy in Child- Pugh C cirrhotic patients with acute cholecystitis. Gut 2006; 55: 898–899.
45
Patel M, Miedema BW, James MA, Marshall JB. Percutaneous cholecystostomy is an effective treatment for high-risk patients with acute cholecystitis. Am Surg 2000; 66: 33–37.
46
Zou YP, Du JD, Li WM et al. Gallstone recurrence after successful percutaneous cholecystolithotomy: a 10-year follow-up of 439 cases. Hepatobiliary Pancreat Dis Int 2007; 6: 199-203.
47
Shrestha R, Trouillot TE, Everson GT. Endoscopic stenting of the gallbladder for symptomatic gallbladder disease in patients awaiting orthotopic liver transplantation. Liver Transplant Surg 1999; 5: 275–281.
48
Wong SK, Yu SC, Lam YH, Chung SS. Percutaneous cholecystostomy and endoscopic cholecystolithotripsy in the management of acute cholecystitis. Surg Endosc 1999; 13: 48–52.
49
Chen YK, Nichols MT, Antillon MR. Peroral cholecystoscopy with electrohydraulic lithotripsy for treatment of symptomatic cholelithiasis in end-stage liver disease. Gastrointest Endosc 2008; 67: 132-135.