Abstract
In this study we aimed to resuscitate the impaired liver functions with exogenous triiodothyronine (T-j) after Pringle maneuver.
Pringle maneuver was performed on dogs for 50 minutes. In the T3 group (n=6), 1.2 µ (g/kg per hour of T3 was administered intravenously for 3 hours after declamping. in the control group (n=6) the same levels of volume of %0.9 SF solution was administered intravenously serum T3 ALT and AST of all dogs before and after declamping in O, 1st, 2nd and 3rd hours were measured. Dogs were observed until the eigth postoperative day.
All the dogs in the control group were in shock after Pringle maneuver and died within 24 hours. All the dogs in T3 group recovered from the shock and survived for 8 days.
In the control group serum ALT and AST levels had a huge increase after declamping. In the T3 group after declamping serum ALT and AST levels increased but not as much as control group and then those serum levels decreased in 2nd and 3rd hours.
Though its exact mechanism is not clear, T3 administration is found to have positive effects in the resuscitation of liver after Pringle maneuver.
