Abstract
Parathyroid carcinomas are rare endocrine tumors and constitute 0,5–5% of hiperparathyroidism incidents and 0,005% of all cancer types. Local recurrence could be observed ranging from 6 months to 3 years. Recurrence earlier than 2 years is a bad prognostic factor. Because of the fact that parathyroid carcinomas are rare and it is unusual to the localization in our study, we aimed to present the incident along with the literature. The patient who has been suffering from dyspnea, chest pain, joint pain, asthenia and weariness for almost 2 years, hypercalcemia, increase in parathormone level and a retrosternal mass was detected. With these findings, the incident was operated parathyroid adenoma pre-diagnoses and was reported as parathyroid carcinoma. Consequently, in the patients who have ectopic localized parathyroid mass and an increase in their blood calcium and parathormone levels, if the size of the mass is large, it should be considered that it may be parathyroid carcinoma and the surgical treatment should be planned with the least recurrence rate.
Keywords:
parathyroid, carcinoma, surgery
References
1Lee PK, Jarosek S, Virnig BA, Evasovich M, Tuttle T. Trend in the incidence and treatment of parathyroid cancer in the United States. Cancer 2007;109:1736- 1741.
2Giessler GA, Beech D. Nonfunctional parathyroid carcinoma. J Natl Med Assoc 2001;93:251-255.
3Erkuş M, Özgün H. Paratiroid karsinomu: olgu sunumu. Ege Tıp Dergisi 2000; 39: 147-151.
4Tan GC, Shiran MS, Swaminathan M, Phang KS, Rohaizak M. Large retrosternal parathyroid carcinoma with primary hyperparathyroidism. Asian J Surg. 2007;30:286-289.
5Hoca O, Bulut A. Paratiroid kanseri: olgu sunumu. İnönü Üniversitesi Tıp Fakültesi Dergisi 2007; 14: 141-143.
6WHO Classification of tumor pathology and genetics tumors of endocrin organs. DeLellis RA, Lloyd RV, Heitz PU, Eng C. IARC Press, Lyon. 2004 :124-127.
7Shane E. Clinical Review: 122 Parathyroid carcinoma. J Clin Endocrinol Metab. 2001;86:485-493.
8Kleinpeter KP, Lovato JF, Clark PB, Wooldridge T, Norman ES, Bergman S, Perrier ND. Is Parathyroid Carcinoma Indeed a Lethal Disease? Ann Surg Oncol 2005; 12:260-266.
9Lee JE. Predicting the Presence of Parathyroid Carcinoma. Annals of Surgical Oncology 2005; 12: 1-2.
10Munson ND, Foote RL, Northcutt RC, Tiegs RD, Fitzpatrick LA, Grant CS, van Heerden JA, Thompson GB, Lloyd RV. Parathyroid Carcinoma: Is There a Role for Adjuvant Radiation Therapy?. Cancer. 2003; 98: 2378-2384.
11Temmim L, Sinowatz F, Hussein WI, Al- Sanea O, El-Khodary H. Intrathyroidal parathyroid carcinoma: a case report with clinical and histological findings. Diagnostic Pathology 2008;3: 46-52.
12Schantz A, Castleman B. Parathyroid carcinoma; a study of the 70 cases. Cancer 1973; 31: 600-605.
13Okamoto T, Iihara M, Obara T, Tsukada T. Parathyroid carcinoma: etiology, diagnosis, and treatment. World J Surg 2009. Epub ahead of print
14Cheah WK, Rauff A, Lee KO, Tan W. Parathyroid carcinoma: a case series. Ann Acad Med Singapore 2005; 34: 443-446.
15Fernandez-Ranvier GG, Khanafshar E, Jensen K, Zarnegar R, Lee J, Kebebew E, Duh QY, Clark OH. Parathyroid carcinoma, atypical parathyroid adenoma, or parathyromatosis? Cancer 2007; 110: 255-