Abstract

Hemorrhagic shock model was created in 18 dogs, and the structural changes of liver, muscle and kidney tissue were histopathologically investigated. Control group was performed in four dogs; the other 14 were constituted as the shock model. All of the 14 were let to bleed. Half of (hem (7 dogs) were then resuscitated with the same amount of blood lost plus Lactated Ringer's solution (RL). The other half (7 dogs) were resuscitated with hypertonic saline solution (HTS) instead of RL besides blood substitution. Histopathologically, there were cellular swelling, vacuolization, necrosis and sinusoidal compression in the hepatocytes; vacuolization and necrosis in the renal cells; separation of myofibrils and disruption of the band pattern in the muscle tissue. It is found that up to the second day after the resuscitation the structural changes of the cells in the organs remained the same and histopathotogically no difference were observed between RL and HTS groups.