Abstract
The effects of hyaluronic acid/carboxymethylcellulose membrane on adhesions and anastomotic healing after Hartmann colostomy closure
Background: Adhesion formation is one of the leading causes of morbidity after abdominal surgery. In this study, it is aimed to investigate effects of anti-adhesive hyaluronic acid/carboxymethylcellulose membrane on adhesions and anastomotic healing after Hartmann colostomy closure in a rat model.
Materials and Methods: Thirty male Wistar-Albino rats are randomised into 3 groups: Standard colostomy (Grup A), standart colostomy + hyaluronic acid/carboxymethylcellulose (Grup B), and control group (Grup C). Adhesions were evaluated by means of a scoring system. Bursting pressure values, and hydroxyproline levels were detected.
Results: Adhesion score of group A (1.7±0.6) was statistically higher compared to group B (1.1±0.3), and to control group C (1.2±0.4) (p<0.05). There was no statistical difference between bursting pressure values, and hydroxyproline levels.
Conclusions: Although hyaluronic acid/carboxymethylcellulose membrane decreased adhesion formation, there was no obvious effect on anastomotic strength and healing. On the other hand, further clinical studies are needed to draw major conclusions.
Keywords:
Hyaluronic acid/carboxymethylcellulose, adhesion, colostomy closure
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