Abstract
Purpose: Follicular adenomas are the most common neoplasms of the thyroid. They are encapsulated and generally solitary lesions. The aim of this study was to assess those patients diagnosed as having follicular adenomas as a result of histopathological examinations during thyroid surgery in our clinic over the last five years and to study the relationship between papillary thyroid carcinoma and follicular adenoma.
Patients and Method: Of the 1081 thyroid operations in the last 5 years, 144 patients who were diagnosed with follicular adenoma as a result of histopathological examination after surgery were assessed.
Results: 104 of the patients (72.2%) were female and 40 (27.7%) were male. When the pathological reports of the patients diagnosed with follicular adenoma were considered, 29 patients (20,1%) also had papillary carcinoma. (p:0.058).
Conclusion: In our study, we commonly detected accompanying follicular adenoma with papillary carcinoma. Because of this, in patients with a diagnosis of follicular neoplasm we consider that surgical treatment should be a total thyroidectomy if there are nodules determined in the same or opposite thyroid lobe.
Keywords:
Papillary carcinoma, follicular adenoma, follicular neoplasm, thyroid
References
1Doherty GM. Follicular neoplasms of the thyroid. In: Clark OH, Quan-Yang Duh. Textbook of endocrine surgery. Philadelphia: W.B. Saunders Company 2005: 115-122. [DOI:10.1016/B978-0-7216-0139-7.50017-X ]
2Rosari J, Carcangiu MI, DeLellis RA. Tumors of Thyroid Gland. In: Firminger HI. Atlas of Tumor Pathology,. 3 rd series, fascicle 5. Washington DC: Armed Forces Institute of Pathology, 1992.
3Maitra A, Abbas AK. The Endocrine System. In: Kumar V, Abbas AK, Fausto N (eds). Pathologic Basis of Disease. 7th ed. Philadelphia: Elseviere Saunders, 2005: 1164–1189.
4İşgör A: Tiroid Hastalıkları ve Cerrahisi. İstanbul: Avrupa Tıp Kitapçılık Yayınları 2000: 347-357.
5Farid P, Gomba S, Peter I, Szende B. Bc12, P53 and bax in thyroid tumors and their relation to apoptosis. Neoplasma 2001; 48: 299-301.
6Castro MR, Gharib H. Thyroid disorders. Thyroid nodules. In: Camacho PM, Gharib H, Sizemore GW. Evidence-based Endocrinology. Philadelphia: Lippincott Williams and Wilkins Co, 2003: 39-73.
7Castro MR, Gharib H. Continuing controversies in the management of thyroid nodules. Ann İntern Med 2005; 142: 926- 931.
8Koike E, Noguchi S, Yamashita H, et al. Ultrasonographic characteristics of thyroid nodules: prediction of malignancy. Arch Surg 2001; 136: 334-337. [DOI:10.1001/arcsurg.136.3.334]
9Erbil Y. Tiroid Nodüllerine ve Tiroid Kanserlerine Cerrahi Yaklaşım. In: Erdoğan MF. Tiroid Bülteni 3 rd. Istanbul: Deha Ozalit, 2009: 6-7.
10Maddox PR, Wheeler MH. Approach to the thyroid nodules. In : Clark OH, Quan-Yang Duh. Textbook of endocrine surgery. ed. Philedelphia, W.B. Saunders Company, 2005: 85-92.
11Lefevre JH, Tresallet C, Leenhardt L, et al. Reoperative surgery for thyroid disease. Langenbecks Arch Surg 2007; 392: 685- 691.[ DOI: 10.1007/s00423-007-0201-6]
12Bender Ö, Yüney E, Çapar H, et al. Total tiroidektomi deneyimlerimiz. Edokrin Diyalog 2004; 1: 15-18.
13Mishra A, Agarwal A, Agarwal G, Mishra SK. Total thyroidectomy for benign thyroid disorders in an endemic region. World J Surg 2001; 25: 307-310. [DOI: 10.1007/s002680020100]
14Giles Y, Boztepe H, Terzioğlu T, Tezelman S. The advantage of total thyroidectomy to avoid reoperation for incidental thyroid cancer in multinodular goiter. Arch Surg 2004; 139: 179-182. [DOI:10.1001/archsurg.139.2.179]
15Bellantone R, Lombardi CP, Bossola M, et al. Total thyroidectomy for management of benign thyroid disease: review of 526 cases. World J Surg 2002; 26: 1468-71. [DOI: 10.1007/s00268-002-6426-1]
16Erbil Y, Barbaros U, Salmaslıoglu A, et al. Effect of thyroid gland volume in preoperative detection of suspected malignant thyroid nodules in a multinodular goiter. Arch Surg 2008; 143: 558-63. [DOI:10.1001/archsurg.143.6.558]