Abstract

The synergistic effects of vitamin E on 32% dextran 70 and aprotinin for the prevention of postoperative intraabdominal adhesions were evaluated. A total of 58 Sprague-Dawley rats were included in control, 32% dextran 70, aprotinin, vitamin E, vitamin £+32% dextran 70, vitamin E+aprotinin groups. Procedure was performed by making three serosal incisions and having a silk suture on the cecum. There were significant adhesions; 80% in the control, 70% in the 32% dextran 70, 60% in the aprotinin, 40% in the vitamin E, 25% in the vitamin E+32% dextran 70 groups. There was no significant adhesions in the vitamin E+aprotinin group, and this was significantly important when it was compared with the control, 32% dextran 70 and aprotinin groups (p<0.05).