An outcome analysis of videoscopic assisted retroperitoneal debridement in infected pancreatic necrosis: a single centre experience

Abstract

Objective: Infected pancreatic necrosis (IPN) is a dreadful complication of moderately severe and severe acute necrotising pancreatitis (ANP). Videoscopic assisted retroperitoneal debridement (VARD) is a minimally invasive surgical option for predominantly left sided, posterior and laterally located disease in patients not responding to conservative and percutaneous options. This study aimed to present an outcome analysis of VARD in the management of IPN at our tertiary care centre.

Material and Methods: The present retrospective analysis of prospectively entered data included 22 patients diagnosed as ANP with IPN from January 2015 to December 2017. These patients were admitted in the surgical gastroenterology unit of our tertiary care centre. The outcome of these patients managed with VARD was evaluated.

Results: The aetiology of ANP was idiopathic, and gallstones were found in 7 patients each and alcohol in 8. Twelve patients were managed with a single VARD procedure; whereas, 10 required a re-debridement due to suboptimal improvement. Eighteen out of 22 patients survived whereas 4 succumbed to major postoperative bleeding/severe sepsis and multiorgan failure (Mortality 18.2%). Hospital stay after the index procedure was between 6 to 11 weeks.

Conclusion: VARD is a safe and effective surgical option for the management of IPN that worsens or fails to respond to conservative and percutaneous drainage options after a minimum of 4 weeks of moderately severe and severe ANP. It decreases postoperative morbidity and mortality and avoids major laparotomy, and hence, it can be considered in a selected group of patients.

Keywords: Videoscopic assisted retroperitoneal debridement, acute necrotising pancreatitis, infected pancreatic necrosis, step up approach

Introduction

Infected pancreatic necrosis (IPN) is one of the most feared complications occurring in approximately 8-12% of patients with moderately severe and severe acute pancreatitis, leading to increased morbidity and mortality (1,2). ‘Step up approach’ for the treatment of IPN has been a paradigm shift in its management (3). Videoscopic assisted retroperitoneal debridement (VARD) is one of the minimally invasive surgical options in the step up approach, used for predominantly left sided, posterior and laterally located disease in patients not responding to conservative, endoscopic and/or percutaneous options (3). The present study analyzes our indications, techniques and outcomes of VARD in the management of moderately severe and severe acute necrotising pancreatitis (ANP) with IPN and provides a brief review of current literature.

Material and Methods

The study was performed after the approval of research protocols by the institutional ethics committee in accordance with international agreements (World Medical Association Declaration of Helsinki “Ethical Principles for Medical Research Involving Human Subjects,” amended in October 2013, www.wma.net)

This observational study is a retrospective evaluation of prospectively entered data of 22 patients admitted with moderately severe and severe ANP with IPN who were managed with VARD from January 2015 to December 2017 in the surgical gastroenterology unit of our tertiary care centre. Severity was assessed as per the 2012 revision of Atlanta classification with modified Marshall scoring system for organ dysfunction. ANP was defined as inflammation associated with pancreatic parenchymal and/or peripancreatic necrosis. Moderately severe acute pancreatitis was defined as transient organ failure (< 48 hours) and/or local or systemic complications; whereas severe acute pancreatitis was defined as persistent (> 48 hours) organ failure (single/multiple) (3). IPN was diagnosed by the presence of clinical features of sepsis/ air foci on contrast enhanced computed tomography (CECT) abdomen or positive cultures in percutaneously drained collections.

The data was retrieved with regards to patient’s demographic profile, etiology, site of necrosum, duration of conservative treatment, drainage, number of VARD procedures done, morbidity, hospital stay and outcome. The patients were evaluated by CECT abdomen at approximately 1 week from the onset of symptoms and on demand during the hospital stay. Our approach to the management of this patient group is as shown in the algorithm (Figure 1).

Figure 1. Algorithm showing our approach to the management of moderately severe and severe acute necrotising pancreatitis as well as patient selection for videoscopic assisted retroperitoneal debridement.

VARD was decided upon after the patients failed to improve or deteriorated (persistent or worsening of multiorgan failure, sepsis, CECT evidence of persistent necrosum) at least 4 weeks after the onset of ANP in spite of treatment with intravenous antibiotics, maximised supportive care in the intensive care unit and percutaneous catheter drainage. In all patients, a 12 Fr catheter was placed percutaneously from the left posterior subcostal approach in the necrotic cavity under computed tomography guidance at least 48 hours prior to VARD procedure.

VARD was then performed with the patient in supine position, under general anaesthesia with the left side elevated by 30 degrees. The representative image of IPN on CECT as shown in was studied and a guided 5 cm left subcostal incision was taken (Figure 2 and 3). The dissection was deepened along the percutaneous catheter until necrotic material was visualised. Gross solid necrotic material was removed under direct vision (Figure 4). A 0° laparoscope was then introduced into the cavity and air insufflated, if required, after temporarily closing the sheath (Figure 5). The remaining necrotic material was then removed under videoscopic guidance and a thorough normal saline wash was given to remove the loose necrosum (Figure 6). Two drains were left in the cavity, 1 superficial and 1 deep, for irrigation and drainage. The patients were taken to the intensive care unit (ICU) after the procedure, and antibiotics, enteral feeding and supportive care were continued. Postoperative lavage 6 litres/day was given with normal saline until the draining fluid was clear. Postoperative hospital course was recorded for the need of repeat VARD or other surgical/endoscopic/percutaneous interventional radiology procedures, postoperative complications, duration of hospital stay, bowel function and management of patient till discharge. All patients were discharged with drains after check CECT scans which also guided drain removal. The patients were followed up at 1 month and 3 months after discharge and then as required. The representative image of one such patient who had undergone VARD followed by repeat procedure via laparoscopic transperitoneal transmesocolic approach is as depicted in Figure 7.

Figure 2. Representative image of infected pancreatic necrosis on contrast enhanced computed tomography.

Figure 3. 5 cm left subcostal incision.

Figure 4. Gross solid necrotic material being removed under direct vision.

Figure 5. 0° laparoscope introduced into the retroperitoneum.

Figure 6. Necrotic material being removed under laparoscopic guidance.

Figure 7. Final postoperative picture with healed incisions.

The complications were defined as follows: Postoperative pancreatic fistula (POPF) was defined as per international study group of pancreatic surgery (ISGPS) as drain output of any measurable volume of fluid with an amylase level > 3 times the upper limit of normal serum amylase, associated with a clinically relevant development/condition related directly to the postoperative pancreatic fistula (4). Superficial incisional, deep incisional and organ space surgical site infections were defined according to the 1992 modified definitions of nosocomial surgical site infection by centre for disease control (CDC) (5). Paralytic ileus was defined as hypomotility of the gastrointestinal (GI) tract in the absence of mechanical bowel obstruction for more than 3 days following the procedure (6). Hemorrhagic complications were divided into intraluminal gastrointestinal haemorrhage or intraabdominal haemorrhage (7). Postoperative course, complications and their management protocol in our department is as shown in Figure 8. All the data was tabulated and analysed.

Figure 8. Algorithm depicting the postoperative course, complications and their management following videoscopic assisted retroperitoneal debridement.

Results

The demographic data of the 22 patients who underwent VARD is listed in Table 1. Mean age of the patients was 48.6 years, 16 of which were male. Mean body mass index was 27.8. Nine patients had diabetes mellitus; whereas, 7 had hypertension. Aetiology was alcohol (8), gall stones (7) and idiopathic (7). All 22 patients had moderately severe or severe acute necrotising pancreatitis. All patients had pancreatic and peripancreatic necroses with minimal fluid documented on CECT scan. Prior CT guided percutaneous catheter drainage was done in all the patients.

Table 1. Patient characteristics, etiology, disease details, treatment details, outcome

The time from diagnosis of ANP to VARD ranged from 32 to 35 days. All patients had a subcostal retroperitoneal approach during the first VARD procedure. 10 patients required a repeat VARD procedure on account of CECT abdomen showing residual or newly formed collection or worsening organ failure. Out of these 10 patients, 5 required one more procedure in the form of laparoscopic (3) or open (2) transperitoneal transmesocolic drainage for central necrotic collection which persisted after the second VARD procedure. Hospital stay after the index procedure was between 6 to 11 weeks.

Thirty two postoperative complications with 4 fatalities were observed, of which 13 were minor and 19 were major complications. Four patients had massive bleeding postoperatively, 3 from a branch of splenic artery and 1 from the gastroduodenal artery. Angioembolisation was done postoperatively and although the bleeding was controlled in these 4 patients, they succumbed to hypovolemia/ongoing sepsis and multiorgan failure. All of these 4 patients had undergone repeat VARD procedures. Nine patients developed superficial surgical site infections whereas 4 developed paralytic ileus.

Of the 18 patients that survived, 4 developed Grade C postoperative pancreatic fistula which were managed by Roux en Y fistulojejunostomy in 2 and distal pancreatectomy in 2 after 6 months of expectant management. In the remaining 14 patients, drain output gradually diminished and drains were removed after a follow up CECT scan. One patient developed colonic fistula which was managed by diversion loop ileostomy.

Discussion

ANP occurs in 5-10% cases of acute pancreatitis (8). Of these, moderately severe and severe acute pancreatitis (SAP) are life threatening conditions associated with high mortality and morbidity (5). The presence of IPN further doubles mortality in SAP (9).

Conventional surgical intervention by open or laparoscopic necrosectomy for IPN is associated with a mortality rate of 25% to 40% (10). The open approach is also associated with relatively higher rates of complications such as bleeding (1-23%), colonic fistula (1-17%) and pancreatic fistula (3-72%) (11). A systematic review by Nieuwenhuijs et al. has concluded that the mortality rates of ANP treated with open abdominal surgery with continuous postoperative lavage remains high, mainly due to multiorgan failure despite optimal surgical and medical treatment.(12) Shifting to VARD as a treatment option might help decrease the morbidity and mortality associated with these open surgeries (13,14). Connor et al. have also proposed that minimally invasive retroperitoneal necrosectomy is a new technique that has shown promising results, and could be preferable to open pancreatic necrosectomy in selected patients (15).

The PANTER trial has shown that a minimally invasive step up approach, as compared with open necrosectomy, reduces the rate of the composite end point of major complications or death among patients with necrotising pancreatitis and infected necrotic tissue (16). Thus, less invasive options such as percutaneous drainage, endoscopic transgastric and laparoscopic transperitoneal necrosectomy have been applied for this indication (9). We also prefer the step up approach at our centre, depending on the location of the necrosum, route of access and local expertise.

The percutaneous endoscopic approaches for necrosectomy were described in the early part of the 21st century, but were associated with many drawbacks viz: time consuming, multiple interventions, incomplete necrosectomy and bleeding (17,18). Carter et al. have proposed that minimally invasive approach for pancreatic necrosectomy has encouraging results but needs further evaluation with larger studies (19). VARD has thus evolved as a result of allowing minimal invasive approach to drain infected pancreatic necrosis without removing the entire solid necrosum in a “step up fashion” (20). VARD can be considered as a hybrid between open necrosectomy and a percutaneous endoscopic approach (1).

VARD is done in cases of established infected pancreatic necrosis after giving a maximised trial of conservative management with intravenous antibiotics, organ support [respiratory, vasopressor, dialysis], and percutaneous drainage techniques (21). Radiological evidence of walled off pancreatic necrosis [WOPN] is essential to plan this minimally invasive procedure (1). The technique involves the placement of a 12-14 french percutaneous catheter in the necrotic cavity through the left retroperitoneum 24-48 hours prior to the VARD procedure. During the procedure, through a small left subcostal incision, the necrotic cavity is reached by following the percutaneous catheter and solid but loose necrosum is removed under vision. This is followed by the insertion of 0° laparoscope and carbon dioxide gas inflated for better vision. The loosely adherent necrosum is further removed, thorough wash given and 2 drains kept (superficial and deep) for postoperative lavage (13).

Variations in the technique described in the literature include variations in the size of incisions, ranging from sinus tract endoscopy to as big as 15 cm translumbar incisions. Also the use of wide range of videoscopes such as laparoscope, nephroscope, cystoscope, mediastinoscope have been described (18). There are wide variations in approach to the necrosum, postoperative operative lavage fluids as well as their volumes infused per day (14,16).

VARD provides an excellent alternative to necrosectomy by laparotomy. Our early results on a few patients as described are comparable to those reported in the literature (9). Horvath et al. have evaluated the safety and efficacy of VARD for IPN in 40 patients using a multicentre, prospective, single arm phase 2 study and concluded that VARD is safe as well as efficacious for IPN (7). Most published data regarding minimally invasive necrosectomy have a postoperative hospital stay ranging between 50 and 64 days which are comparable to our study (17). Re-intervention rates for further necrosectomy may be needed in as high as 73% whereas in our study it was 45.5% (17). The rates of individual complications viz infection, bleeding, fistula as well as mortality were comparable to our study (18.2%) (22). Overall morbidity in different studies has shown wide variation from 0 to 93% and mortality ranging from 10 to 27%. (3) Other studies have shown postoperative bleeding rates (7.5%) compared to ours (18.2%) and similar pancreatic fistula rates (18.2%) (3). Interestingly, our enteric fistula rate (4.5%) was less as compared to others (23,24).

The advantages of VARD include less perioperative stress on an already sick patient, benefit of both limited open and laparoscopic approach, simplicity and cost effectiveness, the disadvantage being the need of undergoing multiple repeat procedures. Also, life-threatening complications are still possible, necessitating close vigilance by a multispecialty team in an intensive care setting.

Study Limitations

The limitations of our study were the relatively small sample size, single centre data and that there were no comparative group of patients.

Conclusion

VARD is a safe and effective surgical option for the management of IPN that worsens or fails to respond to conservative and percutaneous drainage options. Necrosum is debrided and drained using a hybrid open - laparoscopic approach alongside the percutaneously placed catheter. It decreases postoperative morbidity and mortality and avoids major laparotomies and hence, should be considered in the management of this selected group of patients.

Cite this article as: Budkule D, Desai G, Pande P, Narkhede R, Wagle P, Varty P. An outcome analysis of videoscopic assisted retroperitoneal debridement in infected pancreatic necrosis: a single centre experience. Turk J Surg 2019; 35 (3): 214-222.

The study was performed after the approval of research protocols by the institutional ethics committee in accordance with international agreements (World Medical Association Declaration of Helsinki “Ethical Principles for Medical Research Involving Human Subjects,” amended in October 2013, www.wma.net)

Written informed consent was obtained from all patients involved in the study.

Externally peer-reviewed.

Concept - P.W., P.V.; Design - P.W., P.V.; Supervision - G.D., P.P., R.N., P.W., P.V.; Materials - P.W., P.V.; Data Collection and/or Processing - D.B.; Analysis and/or Interpretation - D.B.; Literature Search - D.B.; Writing Manuscript - D.B.; Critical Reviews - G.D., P.P., R.N., P.W., P.V.

No conflict of interest was declared by the authors.

The authors declared that this study has received no financial support.

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