Comparison of fructus agni casti and flurbiprofen in the treatment of cyclic mastalgia in premenopausal women
Tolga Dinç1, Faruk Coşkun2
1Clinic of General Surgery, Dr. Sami Ulus Gynecology and Pediatrics Teaching and Training Hospital, Ankara, Turkey
2Department of General Surgery, Hitit University Faculty of Medicine, Çorum Teaching and Training Hospital, Çorum, Turkey
Abstract
Objective: Cyclic mastalgia is described as a diffuse, periodic and bilateral breast pain that can not be localized. Although there are several methods of treatment, the most efficient treatment method is still controversial. The aim of this study is to determine, compare and discuss the results of the patients under 40 years old age with a complaint of cyclic mastalgia and without any clinical signs, family history and ultrasonography finding, treated with fructus agni casti extract or flurbiprofen.
Material and Methods: One hundred and fourteen premenapousal patients younger than 40 years old with a complaint of cyclic mastalgia and without any clinical, family or ultrasonography findings were analyzed prospectively. Fructus agni casti extract (Group 1) or flurbiprofen (Group 2) were administered to the patients. VAS scores were accepted as full recovery whit a score of zero, as significant healing when the score improved more than 50%, as mild-moderate healing when the improvement was less than 50% and as no healing in case of no improvement.
Results: The mean age in group 1 was 28,29±5,81, and in group 2 was 29,09±4,49. The mean number of days with pain was 6,0±1,70 days in group 1, and was 6,3±1,63 in group 2. There was no significant difference in VAS scores between the two groups after treatment.
Conclusion: Fructus agni casti extract and flurbiprofen are commonly used medications in the treatment of cyclic mastalgia. Both of these medications significantly reduce the complaints and have acceptable side-effects. There is no proven superiority over each other. Further clinical and laboratory studies are necessary to determine the ideal medication fort he treatment of cyclic mastalgia.
Keywords: Mastalgia, Vitex agnus castus, flurbiprofen
Ethics committee approval was received for this study from the ethics committee of Ankara Numune Training and Research Hospital.
Written informed consent was obtained from patients who participated in this study.
Externally peer-reviewed.
Concept - T.D., F.C.; Design - T.D.; Supervision - F.C., T.D.; Funding - F.C., T.D.; Materials - T.D.; Data Collection and/or Processing - T.D.; Analysis and/or Interpretation - F.C., T.D.; Literature Review - F.C.; Writer - T.D.; Critical Review - T.D., F.C.
No conflict of interest was declared by the authors.
The authors declared that this study has received no financial support.