Pediatric renal transplantation; 10 years experience
Gökalp Okut1, Güleç Mert Doğan3, Sait Murat Doğan2
1Department of Gastrointestinal Surgery, Inonu University Faculty of Medicine, Malatya, Turkey
2Department of General Surgery, Inonu University Faculty of Medicine, Malatya, Turkey
3Clinic of Pediatric Radiology, Malatya Research and Training Hospital, Malatya, Turkey
Abstract
Objective: Although renal transplantation (RT) is the first treatment option for children with end-stage renal failure, the number of transplanted chil- dren remains low compared to adults. Experience of the individual pediatric transplant center is very important in the prognosis of pediatric transplant recipients. In this study, our pediatric RT experience was presented.
Material and Methods: We retrospectively analyzed the data of 27 patients who had RT in our clinic between April 2009 and April 2019.
Results: Fifteen of the patients were males, and mean age of all patients was 12.36 ± 4.18 years (range 4-17 years). The most frequent etiology for end- stage renal disease (ESRD) was vesicourethral reflux. Eighteen (66.7%) of the transplanted kidneys came from cadaveric donors and 9 (33.3%) from live donors. One patient had preemptive RT and one patient had a re-RT. Twenty-two patients were on peritoneal dialysis program and four patients were on hemodialysis program. Mean dialysis time before transplantation was 29 (3-104) months. Bleeding was the most common surgical complication. Delayed graft function developed in four patients, and all of their grafts were from cadaveric donors. Rejection developed in 12 of our patients, graft loss was observed in only four of them. Considering all patients, graft survival rates were 100% in the 1st and 3rd years, and 92% in the 5th year.
Conclusion: Pediatric RT program is difficult to establish, maintain and develop. Complications after transplantation are not uncommon; therefore, early detection and appropriate management are needed. Strategies are still needed to increase post-transplant success.
Keywords: Pediatric, end-stage renal disease, renal transplantation
This study approval was obtained from İnönü University Health Sciences Non-Invasive Clinical Researches Ethics Committee (Decision No: 2020/932, 14.07.2020).
Externally peer-reviewed.
Concept - G.O.; Design - G.O.; Supervision - S.M.D.; Materials - G.M.D.; Data Collection and/or Processing - G.O., G.M.D.; Analysis and/or Interpretation - S.M.D.; Literature Search - S.M.D.; Writing Manuscript - G.O.; Critical Reviews - G.M.D.
The authors have no conflicts of interest to declare.
The authors declared that this study has received no financial support.