Şükrü Çolak1, Bünyamin Gürbulak1, Gürhan Çelik1, Hasan Bektaş1, Nevra Dursun2

1Clinic of General Surgery, University of Health Sciences Istanbul Training and Research Hospital, Istanbul, Turkey
2Department of Pathology, University of Health Sciences Istanbul Training and Research Hospital, Istanbul, Turkey


Schwannomas originating from Schwann cells arise from the peripheral nerve sheath and are slow-growing, benign tumors that originate mostly from the mesenchyme. It appears equally in both sexes. Schwannomas are often seen in the 3rd and 5th decades of life. Schwannomas can be seen everywhere where peripheral nerves are seen. Gastrointestinal schwannomas constitute 2-6% of all submucosal masses, and the stomach is the most common region (60-70%). Endoscopic Ultrasound (EUS)-guided sampling of gastrointestinal submucosal lesions has made it possible to achieve preop- erative differential diagnosis. Patients diagnosed with gastrointestinal schwannomas between January 2005 and December 2017 were included in this study. Three out of six patients were females. Median age was 52.5 (44-76) years. Schwannomas were found in two patients in the gastric region, one patient in the appendiceal region, two patients in the colon and one patient in the perianal region. Primary schwannomas are usually benign. Radical resection with free margin is necessary because of the risk of malignant degeneration; chemo and radiotherapy response is indeterminate, and local recurrence rates are high.

Keywords: Gastrointestinal schwannomas, gastrointestinal submucosal mass, immunohistochemistry


Ethics Committee Approval

The ethical approval for this study was obtained from SBÜ İstanbul Training and Research Hospital Clinical Research Ethics Committee (Decision No: 2512, Date: 08.08.2020).

Peer Review

Externally peer-reviewed.

Author Contributions

Concept - Ş.Ç., B.G.; Design - H.B., B.G.; Supervision - H.B.; Materials - Ş.Ç., G.Ç. ND, ; Data Collection and/or Processing - G.Ç., Ş.Ç, N.D.; Analysis and/or Interpretation - H.B., B.G.; Literature Search - B.G.; Critical Reviews - H.B.

Conflict of Interest

No conflict of interest was declared by the authors.

Financial Disclosure

The authors declared that this study has received no financial support.