PROTECTIVE EFFECT OF SURALFATE AND CIMETIDINE ON ETHANOL INDUCED GASTRIC MUCOSAL DAMAGE
NUH ZAFER CANTÜRK1, CİHAN YILDIRIR1, F CAHİT İÇLİ1, ŞENOL KARSLI1, ENDER DÜZCAN2
1Cumhuriyet Üniversitesi Tıp Fakültesi, Genel Cerrahi A.B.D., /SİVAS
2Cumhuriyet Üniversitesi Tıp Fakültesi, Patoloji A.B.D., /SİVAS
Abstract
The efficiacy of sucralfate and cimetidine in protecting against ethanol injury in rat stomach was examined. Rat that had been fasted were pretreated intragastrically with either sucralfate 160 mg/kg, cimetidine 100 mg/kg. One hour later, all rats received 1 ml of 99.5% ethanol orally and were killed 15 minutes later. Stomach was removed, and mucosal damage was assessed macroscopically. Pretreatment with sucralfate significantly reduced the number and extant of ethano-induced mucosa gastric lesions; pretreatment with cimetidine, however, failed to produce positive results. It is concluded that sucralfate protects against ethanol injury.